The Ministry of Science, Research and the Arts of the State of Baden-Württemberg (MWK) supports a new transregional and interdisciplinary research group “antibioPPAP” that aims to develop polycyclic polyprenylated acylphloroglucines (PPAP) as novel antibiotics agains multiresistent enterococci (MRE). Speakers of the consortium are Prof. Friedrich Götz, Interfakultäres Institut für Mikrobiologie und Infektionsmedizin, Tübingen University, and Prof. Bernd Plietker, Institut für Organische Chemie, Stuttgart University. Recently, both groups were able to show that PPAPs are novel non-peptide based antibiotics that show promising activities against MRSA and VRE albeit with moderate to low cytotoxicity. Within the research group scientists of the faculties of chemistry, Stuttgart university, biology, Tübingen university, and university hospital of Ulm are cooperating to optimize the structure-activity relationship, to decrease the toxicity, to improve the pharmacokinetics, and to identify the mode-of-action. The overarching goal is to build a profound knowledge base for PPAP-based antibiotics that pave the way toward clinical studies.
*)original publication: Polycyclic Polyprenylated Acylphloroglucinols: An Emerging Class of Non-Peptide-Based MRSA- and VRE-Active Antibiotics, by Claudia Guttroff, Aslihan Baykal, HuanhuanWang, Peter Popella, Frank Kraus, Nicole Biber, Sophia Krauss, Friedrich Götz und Bernd Plietker, Angew Chem Int Ed Engl. 2017, 56,15852-15856. doi: 10.1002/anie.201707069
Prof. Dr. Friedrich Götz (friedrich.goetz(at)uni-tuebingen.de)
and Prof. Dr. Bernd Plietker